A Novel Murine Model of Human Disseminated Multiple Myeloma with A Subcutaneous Human Bone Chip from an Adult Donor Confers Proliferative Advantage and Is Suitable for the In Vivo Evaluation of Novel Drugs

  1. Ocio, Enrique M. 2
  2. San-Segundo, Laura 3
  3. Blanco, Juan 1
  4. Hernández-Iglesias, Teresa 3
  5. Fernández-Lázaro, Diego 3
  6. Paíno, Teresa 3
  7. Garayoa, Mercedes 3
  8. Álava, Enrique 2
  9. Jiménez-Barredo, Fernando 5
  10. Díaz-Rodríguez, Elena 3
  11. Pandiella, Atanasio 3
  12. San Miguel, J.F 4
  1. 1 Hospital Universitario de Salamanca, Salamanca, Spain,
  2. 2 Hospital Universitario de Salamanca; Centro de Investigación del Cáncer (IBMCC-CSIC-USAL). Spain, Salamanca, Spain,
  3. 3 Centro de Investigación del Cáncer (IBMCC-CSIC-USAL). Spain, Salamanca, Spain,
  4. 4 Hospital Universitario de Salamanca; Centro de InvestigaciÃ, Salamanca, Spain
  5. 5 Servicio de Experimentación Animal. Universidad de Salamanca, Salamanca, Spain,
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Journal:
Blood

ISSN: 0006-4971,  1528-0020

Year of publication: 2021

Volume: 116

Issue: 21

Pages: 4077-4077

Type: Article

DOI: 10.1182/BLOOD.V116.21.4077.4077 GOOGLE SCHOLAR lock_openOpen access editor

More publications in: Blood

Abstract

Several murine models resembling multiple myeloma have been developed in the last years: the subcutaneous plasmocytoma model and the disseminated model, based on the iv or intracardiac injection of MM cells, have been widely used to test the efficacy of novel agents. Nevertheless, it is well known the crucial role that the interaction between MM plasma cells and the bone marrow microenvironment plays in MM pathogenesis as well as in the proliferation of MM cells and drug resistance; however, unfortunately, most murine models do not recapitulate these interactions. In order to overcome this caveat, other models such as the SCIDhu or the SCIDrab have been developed. However, in these models, the induced microenvironmental milleu is derived from a fetus and a rabbit respectively, which can be relatively different from that found in an adult patient with MM. We have developed a novel model of a human disseminated MM with the presence of human adult microenvironment.